IDP has expertise in drug development of novel compounds from formulations to pre-clinical pharmacology including the following:
Tolerability / Safety Testing
Prior to performing efficacy studies in rodents or larger animals, it is critical to asses the tolerability of a novel compound using small groups of animals, with animals being closely monitored for signs of test article related morbidity.
Pharmacokinetics (Biodistribution) / Pharmacodynamics
IDP is able to assess both the action of the drug on target organs as well as metabolic and pharmacokinetic drug parameters through provision of a wide range of services in rodents; including assessment of plasma/serum/ blood and tissue drug levels over time after administration, Organs and tissues may be collected for analysis by LC (liquid chromatography) or radiographic (or other) means to determine drug and metabolite levels. These studies will define the pharmacynamic behaviours of new medicines, where toxicology or efficacy can be correlated to drug distribution and elimination.
IDP has extensive expertise in the development of new tumour models including, subcutaneous (flank, lower back), orthotopic (mammary fat pad, intracranial, other) and syngeneic.
IDP provides professional, SOP-driven preclinical services specializing in human xenograft (orthotopic) and murine (syngeneic) tumour models for screening new drug candidates for anti-cancer efficacy. The xenograft models are based on successful transplantations of human cancer tissue into immuno-compromised mice. Currently a number of validated cancer models (syngeneic and human) are available. Please contact us to request the current list of banked cell lines.
In Vivo Imaging
IDP has the capability of imaging bioluminescence and fluorescence for your in vivo subjects. Our capability has been successfully used to measure and assess disease throughout the course of a study. Disease localization, burden and progression, as well as, response to treatment can all be measured and monitored using our special equipment and techniques.
- In vivo Fluorescent (MAESTRO) / Luminescent (IVIS 200) Imaging
- microPET/CT Imaging
Small Animal Radiation Research Platform (SARRP)
IDP has the capability of delivering CT – guided irradiation, alone and in combination with other drugs. SARRP has been developed to match the standard of care for radiation treatments in a preclinical setting.
Please contact Dr. Nancy Dos Santos to discuss your pre-clinical research needs.